C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/12 (2006.01) A61K 31/40 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 39/06 (2006.01) C07D 207/16 (2006.01) C07D 401/06 (2006.01)
Patent
CA 2414311
The present invention relates to compounds of formula (I), wherein R1, R2, A, X and m are as defined in the description and the claims and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors or metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.
La présente invention concerne des composés de la formule (I) dans laquelle R?1¿, R?2¿, A, X et m sont tels que définis dans le mémorandum descriptif et les revendications. Elle concerne également des formes dimères et/ou des esters pharmaceutiquement acceptables et/ou des sels desdits composés. Ces composés sont utiles comme inhibiteurs de métalloprotéases, telles que les protéases de zinc, notamment les hydrolases de zinc, et sont efficaces dans le traitement de pathologies associées à une vasoconstriction de fréquence accrue.
Aebi Johannes
Blum Denise
Bur Daniel
Chucholowski Alexander
Dehmlow Henrietta
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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