C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/4439 (2006.01) A61P 31/18 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 451/04 (2006.01)
Patent
CA 2647448
The present invention provides compounds of formula (I) wherein R1 to R6 and m are as defined hereinabove. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. Modulators of the CCR5 receptor may be useful in the treatment of various inflammatory diseases, autoimmune diseases, pain, and. in the treatment of infection by HIV and genetically related retroviruses.
La présente invention concerne des composés répondant à la formule (I), R1 à R6 et m étant tels que définis dans le document. Les composés de la présente invention sont des modulateurs, particulièrement des antagonistes, de l'activité des récepteurs CCR5 des chémokines. Les modulateurs des récepteurs CCR5 peuvent être utiles dans le traitement de diverses maladies inflammatoires, maladies auto-immunes, douleurs, et dans le traitement d'infections associées au VIH et à des rétrovirus génétiquement apparentés.
Barber Christopher Gordon
Fenwick David Roy
Pryde David Cameron
Stephenson Peter Thomas
Limited Pfizer
Smart & Biggar
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