Pyrrolidine derivatives as oxytocin antagonists

Details Pyrrolidine derivatives as oxytocin antagonists Pyrrolidine derivatives as oxytocin antagonists

C - Chemistry, Metallurgy

07

D

C07D 207/22 (2006.01) A61K 31/4025 (2006.01) A61P 5/10 (2006.01) C07D 403/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2487532

The present invention relates to novel pyrrolidine derivative of formula (I), its geometrical isomers, its optically active forms as enantiomers, diastereomers, mixtures of these and its racemate forms, as well as salts thereof, wherein R1 is selected from the group comprising or consisting of H and C1-C6-alkyl, for the prevention and/or treatment of preterm labor, premature birth or dysmenorrhea.

La présente invention concerne un nouveau dérivé de pyrrolidine représenté par la formule (I), ses isomères géométriques, ses formes à activité optique utilisées en tant qu'énantiomères, diastéréomères, ou mélanges de ceux-ci, et ses formes racémiques, ainsi que des sels de ceux-ci. Dans la formule (I), R?1¿ est choisi dans le groupe comprenant ou constitué de H et d'alkyle C¿1?-C¿6?. Ce nouveau dérivé peut être utilisé pour prévenir et/ou traiter le travail avant terme, l'accouchement prématuré ou la dysménorrhée.

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