C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) C07D 413/12 (2006.01) C07D 417/14 (2006.01) C07D 455/06 (2006.01)
Patent
CA 2277947
A compound represented by the formula (I): (see formula I) wherein for example, R1 is optionally substituted aralkyl, Z is nitrogen atom which optionally substituted with alkyl, X1 is -CH2NHCO-, X2 is phenylene, X3 is a bond, Y2 is optionally substituted aryl, B is oxygen atom, its pharmaceutically acceptable salt, or hydrate thereof and a composition for inhibiting phospholipase A2 which contains them as an active ingredient together with a pharmaceutically acceptable carrier therfor.
L'invention concerne des composés représentés par la formule générale (I), leurs sels pharmaceutiquement acceptables, ou bien des hydrates de ces composés ainsi que des compositions médicinales contenant lesdits composés, sels ou hydrates comme principe actif. Dans ladite formule (I), par exemple, R<1> représente aralkyle éventuellement substitué, Z représente azote éventuellement alkylé, X<1> représente -CH2NHCO-, X<2> représente phénylène, X<3> représente une liaison simple, Y<2> représente aryle éventuellement substitué, et B représente oxygène.
Ohtani Mitsuaki
Seno Kaoru
Watanabe Fumihiko
Mccarthy Tetrault Llp
Shionogi & Co. Ltd.
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