Pyrrolidine modulators of ccr5 chemokine receptor activity

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/675 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) C07D 209/44 (2006.01) C07D 209/52 (2006.01) C07D 401/00 (2006.01) C07D 401/14 (2006.01) C07D 403/00 (2006.01) C07D 405/14 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01) C07F 9/02 (2006.01) C07F 9/06 (2006.01) C07F 9/28 (2006.01) C07F 9/547 (2006.01)

Patent

CA 2425288

Pyrrolidine compounds of Formula (I), (wherein R1, R2, R3, R4, R5, R6a, R6b, R7 and R8 are defined herein) are described. The compounds are modulators of CCR5 chemokine receptor activity. The compounds are useful, for example, in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

La présente invention concerne des composés à base de pyrrolidine, de formule (I), dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6a¿, R?6b¿, R?7¿ et R?8¿ sont tels que définis dans la description. Ces composés sont des modulateurs de l'activité de récepteur de chimiokines CCR5 et sont utilisés, par exemple, dans la prévention ou le traitement d'infections à VIH et dans le traitement du sida, sous forme de composés ou de sels de ceux-ci, acceptables d'un point de vue pharmaceutique, ou sous forme d'ingrédients dans des compositions pharmaceutiques, éventuellement en association avec d'autres agents antiviraux, immunomodulateurs, antibiotiques ou vaccins. La présente invention concerne également des procédés pour traiter le sida, ainsi que des procédés pour prévenir ou traiter des infections à VIH.

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