Pyrrolidine modulators of chemokine receptor activity

Details Pyrrolidine modulators of chemokine receptor activity Pyrrolidine modulators of chemokine receptor activity

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/4155 (2006.01) A61K 31/4178 (2006.01) A61K 31/4192 (2006.01) A61K 31/4196 (2006.01) A61K 31/422 (2006.01) A61K 31/4245 (2006.01) A61K 31/427 (2006.01) A61K 31/433 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) A61K 31/4439 (2006.01) A61K 31/445 (2006.01) A61K 31/4523 (2006.01) A61K 31/454 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61P 9/10 (2006.01) A61P 31/18 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) C07D

Patent

CA 2373717

The present invention is directed to pyrrolidine compounds of formula (I) (wherein R1, R2, R3, R4, R5, R6, R14 and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR- 3.

La présente invention concerne des composés de pyrrolidine de formule (I) (dans laquelle: R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?14¿ et n sont tels que définis dans la description) utiles en tant que modulateurs de l'activité du récepteur de la chimiokine. En particulier ces composés sont utiles en tant que modulateurs des récepteurs CCR-5 et/ou CCR-3 de la chimiokine.

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