Pyrrolidine oxadiazole- and thiadiazole derivatives

Details Pyrrolidine oxadiazole- and thiadiazole derivatives Pyrrolidine oxadiazole- and thiadiazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/401 (2006.01) A61K 31/4025 (2006.01) A61K 31/4245 (2006.01) A61P 15/00 (2006.01) C07D 207/00 (2006.01) C07D 207/14 (2006.01) C07D 271/00 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2449578

The present invention is related to pyrrolidine oxadiazole and thiadiazole derivatives for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such pyrrolidine oxadiazole derivatives. Said pyrrolidine derivatives are useful in the treatment and/or prevention of preterm labor, premature birth and dysmenorrhea. In particular, the present invention is related to pyrrolidine derivatives displaying a substantial modulatory, notably an antagonist activity of the oxytocin receptor. More preferably, said compounds are useful in the treatment and/or prevention of disease states mediated by oxytocin, including preterm labor, premature birth and dysmenorrhea. The present invention is furthermore related to novel pyrrolidine derivatives as well as to methods of their preparation. (I) B is a oxadiazole or thiadiazole group.

La présente invention concerne de dérivés de pyrrolidine oxadiazoles et thiadiazoles utilisables dans des composés pharmaceutiquement actifs, ainsi que les préparations pharmaceutiques contenant de tels dérivés de pyrrolidine oxadiazole. Lesdits dérivés de pyrrolidine oxadiazoles sont utiles dans le traitement et/ou la prévention d'accouchement avant terme, d'accouchement prématuré et la dysménorrhée. En particulier, la présente invention concerne les dérivés de pyrrolidine présentant une activité sensiblement modulatrice, notamment une activité antagoniste du récepteur d'oxytocine. De manière plus avantageuse, lesdits composés sont utiles dans le traitement et/ou la prévention de maladies provoquées par l'oxytocine, y compris l'accouchement avant terme, l'accouchement prématuré et la dysménorrhée. En outre, la présente invention concerne les nouveaux dérivés de pyrrolidine ainsi que leurs procédés de préparation. Formule (I), dans laquelle B est un groupe oxadiazole ou thiadiazole.

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