C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/480.1, 260/4
C07C 101/20 (1980.01)
Patent
CA 1091689
ABSTRACT Intermediates useful for preparing compounds which possess anti-gastric secretion activity cardiovascular activity, e.g. antihypertensive acitiity, platelet aggregation inhibition activity, respiratory tract activity, e.g. bronchodilator activity and antifertility and smooth muscle activity. The intermediates are of formula (A) or (IX). Image (A) wherein: n is 1 to 8; y is CH2CH2 or CH=CH; R1 is hydrogen, CH2OH, CH2OH in which the OH moiety is protected, CO2W wherein W is hydrogen or CO2W represents an ester group in which the ester moiety contains form 1 to 12 carbon atoms, or CONH2; CO2R7 is a group CO2W as defined; R2 is hydrogen C1-4 alkyl, or taken together with R3 and the carbon atom to which is is attached represents a carbonyl group; R3 is hydrogen, hydroxy or protected hydroxy; R4 is hydrogen or C1-9 alkyl; and salts thereof.
350652
Cassidy Frederick
Wootton Gordon
Beecham Group Limited
Borden Ladner Gervais Llp
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