Pyrrolidine, piperidine and azepidine prostaglandin analogues

Details Pyrrolidine, piperidine and azepidine prostaglandin analogues Pyrrolidine, piperidine and azepidine prostaglandin analogues

C - Chemistry, Metallurgy

07

D

260/325.3, 260/2

C07D 207/36 (2006.01) C07C 405/00 (2006.01) C07D 207/26 (2006.01) C07D 211/40 (2006.01) C07D 211/42 (2006.01) C07D 211/74 (2006.01) C07D 211/86 (2006.01) C07D 491/10 (2006.01)

Patent

CA 1088062

ABSTRACT Pharmacological compounds of the formula (I): Image (I) stereoisomers and pharmaceutically acceptable salts thereof wherein; X is CO, protected CO, CROH in which R is hydrogen or C1-4 alkyl and in which the OH moiety may be protected; Y is CH2CH2; Z is CO or CH2; n is 1 to 7; m is 1, 2 or 3; R1 is hydrogen, CH2OH, CH2OH in which the OH moiety is protected, CO2 W wherein W is hydrogen or C1- 4 alkyl; R2 is hydrogen, C1-4 alkyl, or taken together with R3 and the carbon atom to which it is attached represents a carbonyl group; R3 is hydrogen, hydroxy or protected hydroxy; R4 is hydrogen, or C1-9 alkyl. Methods for preparing the compounds are also described The compounds possess anti-gastric secretion activity cardiovascular activity, e.g. anti- hypertensive activity, platelet aggregation inhibition activity, respiratory tract activity, e.g. bronchodilator activity and antifertility and smooth muscle activity.

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