A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4025 (2006.01) A61K 31/00 (2006.01) A61P 35/02 (2006.01)
Patent
CA 2761182
The present invention relates to a combination for the treatment of cancer wherein the combination exhibits a synergistic effect. The combination comprises radiation and at least one cyclin dependent kinase (CDK) inhibitor selected from the compounds of formula I or a pharmaceutically acceptable salt or a solvate thereof. The present invention also relates to a method for the treatment of cancer, which method comprises administering to a patient in need of such a treatment, a therapeutically effective amount of the combination. The present invention also relates to the use of a CDK inhibitor selected from the compounds of formula I as a radiosensitizer that enhances the efficacy of radiotherapy for the treatment of cancer, particularly head and neck cancer.
La présente invention concerne une combinaison destinée au traitement du cancer, la combinaison présentant un effet synergique. La combinaison comprend des radiations et au moins un inhibiteur de kinase cycline-dépendante (CDK) choisi parmi les composés de formule I ou l'un de leurs sels pharmaceutiquement acceptables ou solvates. La présente invention a également pour objet une méthode de traitement du cancer, laquelle méthode comprend l'administration à un patient ayant besoin d'un tel traitement, d'une quantité thérapeutiquement efficace de la combinaison. La présente invention concerne également l'utilisation d'un inhibiteur de CDK choisi parmi les composés de formule I en tant que radiosensibiliseur qui amplifie l'efficacité de la radiothérapie pour le traitement du cancer, particulièrement le cancer de la tête et du cou.
Hebbar Nikhil Krishnamurthy
Joshi Kalpana Sanjay
Rathos Maggie Joyce
Sharma Somesh
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Piramal Life Sciences Limited
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