C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/233, 260/306
C07D 207/16 (2006.01) A61K 31/40 (2006.01) C07D 403/06 (2006.01)
Patent
CA 1326033
NOVEL PYRROLIDINEAMIDE DERIVATIVE HAVING ANTI-PROLYL ENDOPEPTIDASE ACTIVITY Abstract: A novel pyrrolidineamide derivative that exhibits inhibitory activity toward prolyl endopeptidase and its use as an inhibitor against said enzyme are provided. The pyrrolidineamide of the invention has the following general formula: Image (I) wherein R1 is benzyloxycarbonyl or a group of the formula: Image (wherein m is an integer of from 1 to 5) and R2 is hydroxy, acyloxy or a group of the formula: Image or Image (wherein R3 and R4 independently are a hydrogen atom, a halogen atom, a lower alkyl or a lower alkoxy).
551797
Fukami Harukazu
Hashimoto Masaki
Higuchi Naoki
Saitoh Masayuki
Tanaka Takaharu
Suntory Limited
Swabey Ogilvy Renault
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