C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/231, 167/233
C07D 295/18 (2006.01) C07D 207/16 (2006.01) C07D 295/185 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01)
Patent
CA 1320734
PYRROLIDINEAMIDE DERIVATIVE OF ACYLAMINO ACID AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME Abstract: A compound of the general formula: Image (1) wherein m is an integer of 1 to 7, n is 0 or an integer of 1 to 5, R1 is the phenyl, a substituted phenyl, the phenoxy, a substituted phenoxy or a saturated or unsaturated straight alkyl having 5 to 18 carbon atoms, R2 is hydrogen atom, R3 is hydrogen atom, a branched or unbranched alkyl having 3 to 5 carbon atoms, the phenyl, hydroxyphenyl, benzyloxyphenyl, an alkylthio having 1 to 3 carbon atoms in its alkyl moiety, amino, carboxyl, hydroxy, benzyloxy, indolyl or imidazolyl, or R2 and R3 together form a single bond between the carbon atom and the nitrogen atom, and a pharmaceutical composition containing said compound are provided. The compound is effective in curing amnesia because of its anti-prolyl endopeptidase activity.
528630
Fukami Harukazu
Hashimoto Masaki
Higuchi Naoki
Saitoh Masayuki
Tanaka Takaharu
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Suntory Limited
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