C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/5377 (2006.01) A61P 7/02 (2006.01) C07D 207/16 (2006.01) C07D 263/04 (2006.01) C07D 265/32 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 413/06 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2521069
The invention relates to the compounds of formula (I), wherein W represents N, CR3, or a sp2 hybridized C atom, E, together with W, represents a 3- to 7- membered saturated carbocylic or heterocyclic ring having 0 to 3 N atoms, 0 to 2 O atoms and/or 0 to 2 S atoms, which ring may contain a double bond, D represents a mononuclear or binuclear unsubstituted aromatic carbocycle or heterocycle having 0 to 4 N atoms, O atoms and/or S atoms or being monosubstituted or polysubstituted by Hal, A, OR3, N(R3)2, NO2, CN, COOR3 or CON(R3)2, G represents -[C(R4)2]n-, -[C(R4)2]nNR3-, -[C(R4)2]nO-, -[C(R4)2]nS- or -[C(R4)=C(R4)]n-, X represents -[C(R4)2]nCONR3[C(R4)2]n-, - [C(R4)2]nNR3CO[C(R4)2]n-, -[C(R4)2]nNR3[C(R4)2]n-, -[C(R4)2]nO[C(R4)2]n-, - [C(R4)2]nCO[C(R4)2]n- or -[C(R4)2]nCOO[C(R4)2]n-, Y represents alkylene, cycloalkylene, Het-diyl or Ar-diyl, T represents a mononuclear or binuclear saturated or unsaturated carbocycle or heterocycle having 0 to 4 N atoms, O atoms and/or S atoms, which is monosubstituted or polysubstituted by =O, =S, =NR3, =N-CN, =N-NO2, =NOR3, =NCOR3, =NCOOR3, =NOCOR3 and which may further be monosubstituted, disubstituted or trisubstituted by R3, Hal, A,-[C(R4)2]n, - Ar, -[C(R4)2]n-het, -[C(R4)2]n-cycloalkyl, OR3, N(R3)2, NO2, CN, COOR3, CON(R3)2, NR3COA, NR3CON(R3)2, NR3SO2A, COR3, SO2NR3 and/or S(O)nA, and R1 and R2 are defined as in claim 1. The inventive compounds inhibit coagulation factor Xa and can be used in the prophylaxis and/or therapy of thrombo-embolic diseases and for treating tumors.
L'invention concerne de nouveaux composés de formule (I), dans laquelle D, E, G, W, X, Y, T, R?1¿ et R?2¿ ont les désignations spécifiées dans la revendication 1. Ces composés sont des inhibiteurs du facteur de coagulation Xa et peuvent être utilisés pour la prophylaxie et/ou la thérapie de maladies thrombo-embolitiques et pour le traitement de tumeurs.
Cezanne Bertram
Dorsch Dieter
Gleitz Johannes
Mederski Werner
Tsaklakidis Christos
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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