Pyrrolidinohydrochinazolines

Details Pyrrolidinohydrochinazolines Pyrrolidinohydrochinazolines

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) C07D 471/14 (2006.01) C07D 491/14 (2006.01) C07D 495/14 (2006.01)

Patent

CA 2515730

The invention relates to the novel compounds of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof, wherein the groups Ar1, Ar2, A, R1, R2, R3, E1, E2, X and n are as defined in the description and claims, which are effective modulators of chemokine activity.

Cette invention a trait à de nouveaux composés correspondant à la formule (I) ou à leurs stéréo-isomères ou encore a leurs sels acceptables du point de vue pharmaceutique. Dans cette formule les groupes Ar?1¿, Ar?2¿, A, R?1¿, R?2¿, R?3¿, E?1¿, E?2¿ et X ainsi que la valeur de n sont tels que définis dans le descriptif et les revendications. Ces composés se révèlent d'efficaces modulateurs de l'activité de la chimiokine.

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