Pyrrolidinone glucokinase activators

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/12 (2006.01) A61K 31/4155 (2006.01) A61P 3/10 (2006.01) C07D 401/12 (2006.01) C07D 405/14 (2006.01) C07D 417/12 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2720524

Provided herein are compounds of the formula (I): wherein X, R1, R2 and R3 are as defined in the specification, as well as pharmaceutically acceptable salts thereof. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.

La présente invention concerne des composés représentés par la formule (I) dans laquelle X, R1, R2 et R3 sont tels que défini dans la spécification, ainsi que certains sels pharmaceutiquement admis de ces composés. Ces composés, et les compositions pharmaceutiquement les contenant, conviennent au traitement d'affections et de troubles du métabolisme tels que, par exemple le diabète de type 2.

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