C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/14 (2006.01) A61K 31/404 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2690799
The present invention relates to pyrrolidin-2-one, pyrrolidin-2, 5-dione, pyrrolidine and thiosucciniroide compounds of formulae (I) - (IV), and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrrolidin-2-one, pyrrolidin-2, 5-dione, pyrrolidine and thiosuccinimide compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound of pyrrolidin-2-one, pyrrolidin-2, 5-dione, pyrrolidine and thiosuccinimide compound of the present invention.
La présente invention concerne des composés de pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine et thiosuccinimide représentés par les formules I) - (IV), et des procédés de préparation de ces composés. La présente invention concerne également des compositions pharmaceutiques contenant les composés de pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine et thiosuccinimide. La présente invention concerne des procédés de traitement d'un trouble de prolifération cellulaire, tel qu'un cancer, par l'administration à un patient la nécessitant d'une quantité thérapeutiquement efficace d'un composé de pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine et thiosuccinimide de la présente invention.
Ali Syed M.
Ashwell Mark A.
Hill Jason
Kelleher Eugene
Liu Yanbin
Arqule Inc.
Mcfadden Fincham
LandOfFree
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