Pyrrolidinyl di-carboxylic acid derivatives as metabotropic...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 207/16 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2204767

The present invention provides substituted pyrrolidines that affect certain excitatory amino acid receptors, and are useful in the treatment of neurological disorders and psychiatric disorders. Specifically, the compounds of the present invention are active as agonists of the metabotropic glutamate receptor subtype mGluR2.

L'invention porte sur des pyrrolidines substituées, modifiant certains récepteurs excitatifs d'acides aminés et s'avérant utiles dans le traitement de troubles d'ordre neurologique et psychiatriques. Les composés objets de l'invention sont des agonistes actifs du sous-type mGluR2 du récepteur métabotrope du glutamate.

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