C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61K 31/437 (2006.01) A61P 5/00 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2669357
Compounds represented by formula (I) or (II) against cell releasing TNF .alpha., their pharmaceutically acceptable salts or hydrates and preparation methods and uses thereof, in which A and B represent CH2, CO, SO, SO2 respectively; D represents S, NH, NC1-6 alkyl; R1 represents H, one-two same or different radical(s) selected from the group consisting of F, Cl, Br, C1-4 alkyl,OH,OC1-4 alkyl,NO2,NHC(O)C1-4 alkyl,NH2,NH(C1-4 alkyl),N(C1-4 alkyl)2.
L'invention concerne des composés représentés par la formule (I) ou (II) agissant contre des cellules qui libèrent le facteur de nécrose tumorale alpha, TNF .alpha., les sels ou hydrates de qualité pharmaceutique de ceux-ci ainsi que des procédés de préparation et les utilisations de ces composés. Dans ces formules, A et B représentent CH2, CO, SO, SO2 respectivement; D représente S, NH, NC1-6 alkyle; R1 représente H, un ou deux radicaux identiques ou différents sélectionnés dans le groupe constitué par F, Cl, Br, C1-4 alkyle,OH,OC1-4 alkyle,NO2,NHC(O)C1-4 alkyle,NH2,NH(C1-4 alkyle),N(C1-4 alkyle)2.
Miltons Ip/p.i.
Tianjin Hemay Bio-Tech Co. Ltd.
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