Pyrroline n-oxide derivatives

Details Pyrroline n-oxide derivatives Pyrroline n-oxide derivatives

C - Chemistry, Metallurgy

07

D

C07D 207/46 (2006.01) C07D 403/12 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2083977

PYRROLINE N-OXIDE DERIVATIVES ABSTRACT Derivatives of 3,5-substituted pyrroline N-oxides having substituents in the 4-position have been prepared, with the 4- position substituents being selected from certain ester, polyether, and alkanoyl groups, the latter having components which bind to biological substrates. These specific derivatives are effective as spin traps for different types of free radicals to form persistent nitroxide adducts of extended half life. These adducts can be characterized by ESR spectrometry technique and provide information e.g. concerning the identification of free radicals.

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