C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 33/30 (2006.01) A61K 31/40 (2006.01) A61K 38/03 (2006.01) C07D 207/36 (2006.01) C07D 207/38 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07F 7/08 (2006.01) C07K 4/00 (2006.01) C07K 14/82 (2006.01)
Patent
CA 2196608
Novel pyrrolinone-based compounds mimic or inhibit the biological and/or chemical activity of peptides, including peptide .beta.-strand conformations. Certain compounds contain functionalized pyrrolinone units in place of one or more amino acids of a target peptide.
Cette invention se rapporte à de nouveaux composés à base de pyrrolinones, qui imitent ou inhibent l'activité biologique et/ou chimique des peptides, y compris les conformations des brins .beta. de peptides. Certains de ces composés contiennent des unités pyrrolinones fonctionnalisées à la place d'un ou de plusieurs acides aminés d'un peptitde cible.
Guzman Mark
Hirschmann Ralph F.
Holcomb Ryan C.
Keenan Terence
Pasternak Alexander
Borden Ladner Gervais Llp
The Trustees Of The University Of Pennsylvania
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