Pyrrolizidine derivative

Details Pyrrolizidine derivative Pyrrolizidine derivative

C - Chemistry, Metallurgy

07

D

260/299

C07D 487/04 (2006.01)

Patent

CA 1255315

Abstract of the disclosure: A novel pyrrolizidine derivative of the formula, Image which has potent antiarrhythmic activity and low toxicity is produced. The derivative can be synthesized. by acylating 2,6-xilidine to protect the amino group, nitrating the protected xilidine to introduce a nitro group at 3-posi- tion, reducing the nitro group to an amino group, followed by diazotizing and hydrolyzing, and then the resulted 3-hydroxy-2,6-dimethylaniline being condensed with 8-halocarbonylmethylpyrrolizidine; or by nitrating N-(2' ,6- '-dimethyl)phenyl-8-pyrrolizidineacetamide to introduce a nitro group at 3'-positions, reducing the nitro group to amino group, diazotizing the amino group and hydrolyzing the diazonium compound.

475041

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