Pyrrolo¬1,2-a| ¬4,1|benzoxazepine derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 498/04 (2006.01) A61K 31/55 (2006.01) C07D 519/00 (2006.01)

Patent

CA 1273335

4-15722/CGC 1176 Pyrrolo[1,2-a][4,1]benzoxazepine derivatives Abstract of the Disclosure Disclosed are the compounds of the formula Image (I) wherein n represents the integer 1, 2, 3 or 4; R1 represents hydrogen, lower alkyl, halogen, trifluoromethyl, hydroxy or lower alkoxy; R2 represents hydrogen or lower alkyl; R3 represents hydrogen, lower alkyl or halogen; R4 represents amino, lower alkylamino, di-lower alkylamino, morpholino, N-lower alkyl or N-aryl-piperazino, pyrrolidino, piperidino or substituted piperidino selected from Image in which R5 represents hydrogen, halogen or lower alkyl; and pharmaceutically acceptable salts thereof; which are useful in mammals as calmodulin antagonists for the treatment of gastrointe- stinal disorders.

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