Pyrrolo (1,2-b) pyridazine compounds and their use as cfr-1...

Details Pyrrolo (1,2-b) pyridazine compounds and their use as cfr-1... Pyrrolo (1,2-b) pyridazine compounds and their use as cfr-1...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2521191

Disclosed are novel CRF receptor antagonists and their use as treatment of a variety of disorders, including disorders manifesting hypersecretion of CRF or associated with CRF or CRF receptors, such as anxiety, and depression. CRF receptor antagonists of the invention have the structure of formula (I): including stereoisomers or mixture of stereoisomers, pharmaceutically acceptable prodrugs, or pharmaceutically acceptable salts thereof, wherein in formula (I) R is H or Me.

L'invention concerne des antagonistes nouveaux du récepteur de corticolibérine et leur utilisation dans le traitement de troubles divers, y compris des troubles qui manifestent une hypersécrétion de corticolibérine ou qui sont associés à la corticolibérine ou aux récepteurs de corticolibérine, tels que l'anxiété et la dépression. Les antagonistes du récepteur de corticolibérine ont la structure de formule (I), dans laquelle R désigne H ou Me. L'invention concerne également les stéréoisomères ou mélanges de stéréoisomères des antagonistes de formule (I), leurs promédicaments pharmaceutiquement acceptables ou leurs sels pharmaceutiquement acceptables.

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