Pyrrolo[2,1-b][1,3]benzothiazepines with atypical...

Details Pyrrolo[2,1-b][1,3]benzothiazepines with atypical... Pyrrolo[2,1-b][1,3]benzothiazepines with atypical...

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/554 (2006.01) A61P 25/18 (2006.01) C07D 209/00 (2006.01) C07D 281/00 (2006.01)

Patent

CA 2338651

New polycondensated heterocycles with a pyrrolo[2,1-b][1,3]benzothiazepine structure of the formula (I), where the groups defined as in the description are disclosed. As compared to known antipsychotic agents, the compounds according to the invention present substantial activity associated with a simultaneous reduction in unwanted extrapyramidal symptoms. The compounds which are the subject of the invention described herein can be formulated in pharmaceutical compositions for the treatment of psychoses such as, for example, schizophrenia.

La présente invention concerne de nouveaux hétérocycles polycondensés à structure pyrrolo[2,1-b][1,3]benzothiazépines représentée par la formule (I), dans laquelle ces groupes sont tels que définis dans le descriptif. Par rapport aux agents antipsychotiques connus, les composés de cette invention présentent une importante activité associée à la diminution simultanée des symptômes extrapyramidaux indésirables. Ces composés peuvent être formulés dans des compositions pharmaceutiques destinées au traitement des psychoses telles que la schizophrénie, par exemple.

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