C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 519/00 (2006.01) A61K 31/5517 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2520897
The present invention relates to novel pyrrolo[2,1-c][1,4]benzodiazepines useful as potential antitumour agents. This invention relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepines useful as antitumour agents. More particularly, it provides a process for the preparation of 1,1'- {[(bisalkane-1,N-diyl)piperazine]dioxy} bis[(11aS)-7-methoxy-1, 2, 3, 11a- tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one, with aliphatic chain length variations for the compounds and it also describes the anticancer (antitumour) activity. The structural formula of novel pyrrolo[2,1-c][1,4]benzodiazepine is as follows, wherein n = 2 to 10. (see formula VI)
La présente invention concerne des analogues de 1,1~-{[(bisalkane-1,N-diyl)piperazine]dioxy}bis(11aS)-7-méthoxy-1,2,3,11a-tétrahydro-5H-pyrrolo[2,1-c] [1,4]benzodiazépin-5-one] répondant à la formule (VI) dans laquelle n vaut de 2 à 10, une composition pharmaceutique renfermant lesdits analogues, ainsi que leur procédé de préparation.
Kamal Ahmed
Reddy Depatla Rajasekhar
Reddy Peram Surakattula Murali Mohan
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Council Of Scientific And Industrial Research
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