Pyrrolo[2,1-c][1,4]benzodiazepine hybrids and a process for...

Details Pyrrolo[2,1-c][1,4]benzodiazepine hybrids and a process for... Pyrrolo[2,1-c][1,4]benzodiazepine hybrids and a process for...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/5517 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2660799

The present invention provides a compound of general formula (5), useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo [2,1-c][1,4] benzodiazepine hybrids of general formula (5) X1 X2 X3 = H (or) Cl (or) CH3 Y = O (or) NH Z = C=O (or) CH2 wherein, X1, X2, X3 is selected from H or Cl or CH3, Y is selected from O or NH, Z is selected from C =0 or CH2 and n=1 to 4.

L'invention concerne un composé de formule générale 5, que l'on utilise comme puissants agents antitumoraux contre des lignées cellulaires cancéreuses humaines. L'invention concerne en outre un procédé de préparation d'hybrides pyrrolo[2,1-c][1,4]benzodiazépine de formule générale 5 X1 X2X3 = H (ou) Cl (ou) CH3 Y = O (ou) NH Z = C=O (ou) CH2, dans laquelle X1 X2X3 est choisi dans H ou Cl ou CH3, Y dans O ou NH, Z dans C=O ou CH2 et n=1 à 4.

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