C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4745 (2006.01) A61P 13/12 (2006.01)
Patent
CA 2755197
N-[3-(4-Cyano-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-4- trifluoromethyl-benzenesulfon- amide, N-[3-(4-ethynyl-1H-pyrrolo[2,3-b]pyridinc-3-carbonyl)- 2,4-difluoro- phenyl]-4-trifluoromethyl-benzenesulfonamide, and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one Raf protein kinase. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of Raf protein kinases, including pain and polycystic kidney disease.
L'invention concerne N-[3-(4-Cyano-l H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phényl]-4- trifluorométhyl-benzènesulfonamide, N-[3-(4-éthynyl-lH-pyrrolo[2,3-b]pyridinc-3-carbonyl)- 2,4-difluoro-phényl]-4-trifluorométhyl-benzènesulfonamide et leurs sels, leurs formulations, leurs conjugués, leurs dérivés, leurs formes et utilisations. Dans certains aspects et modes de réalisation, les composés ou leurs sels, leurs formulations, leurs conjugués, leurs dérivés, leurs formes sont actifs sur au moins une protéine kinase Raf. L'invention concerne également leurs procédés d'utilisation pour traiter des maladies et états pathologiques, y compris des maladies et états pathologiques associés à l'activité des protéines kinases Raf, notamment la douleur et la maladie polykystique des reins.
Ibrahim Prabha N.
Spevak Wayne
Mbm Intellectual Property Law Llp
Plexxikon Inc.
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