Pyrrolo [2, 3. b] pyridines which inhibit raf protein kinase

Details Pyrrolo [2, 3. b] pyridines which inhibit raf protein kinase Pyrrolo [2, 3. b] pyridines which inhibit raf protein kinase

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2759997

Compounds (I) and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, and forms thereof are active on each of BRaf and c-Raf -1 protein kinase, and may also be active on either or both of A-Raf and B-Raf V600E protein kinase. Also described are methods of use thereof to treat diseases and conditions, including melanoma, colorectal cancer, thyroid cancer, ovarian cancer, and biliary tract cancer.

L'invention porte sur des composés (I) et des sels de ceux-ci, sur des formulations de ceux-ci, sur des conjugués de ceux-ci, sur des dérivés de ceux-ci, sur des formes de ceux-ci et sur leurs utilisations. Sous certains aspects et modes de réalisation, les composés décrits ou sels de ceux-ci, formulations de ceux-ci, conjugués de ceux-ci, dérivés de ceux-ci et formes de ceux-ci sont actifs sur chacune des protéines kinases BRaf et c-Raf-1, et peuvent également être actifs sur l'une ou l'autre protéine kinase A-Raf ou B-Raf V600E ou sur les deux. L'invention porte également sur des procédés d'utilisation des composés pour traiter des maladies et des états pathologiques, tels qu'un mélanome, un cancer colorectal, un cancer de la thyroïde, un cancer de l'ovaire et un cancer du tractus biliaire.

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