C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 519/00 (2006.01) A61K 31/437 (2006.01) A61P 19/02 (2006.01) A61P 37/08 (2006.01)
Patent
CA 2727315
Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (A) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
La présente invention concerne des composés décrits par la formule chimique (I) ou des sels pharmaceutiquement acceptables de ceux-ci qui : (A) sont des inhibiteurs de p38 et sont utiles dans le traitement de linflammation, par exemple dans le traitement de lasthme, la polyarthrite rhumatoïde, la spondylarthrite ankylosante, larthrose, la goutte et dautres pathologies arthritiques ; des articulations enflammées, leczéma, le psoriasis ou dautres pathologies inflammatoires de la peau telles que les coups de soleil ; des pathologies oculaires inflammatoires comprenant la conjonctivite ; le pyrosis, la douleur et dautres pathologies associées à linflammation.
Chen Meng-Hsin
Dykstra Kevin D.
Koyama Hiroo
Meinke Peter T.
O'keefe Stephen J.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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