Pyrrolo(2,3-d)carbazole derivatives and preparation thereof

Details Pyrrolo(2,3-d)carbazole derivatives and preparation thereof Pyrrolo(2,3-d)carbazole derivatives and preparation thereof

C - Chemistry, Metallurgy

07

D

260/298.5

C07D 487/04 (2006.01) C07D 471/04 (2006.01) C07D 471/20 (2006.01) C07D 487/10 (2006.01)

Patent

CA 1185605

ABSTRACT OF THE DISCLOSURE This invention relates to novel alkyl pyrrolo- (2,3-d)carbazole-6-carboxylates of the formula Image and to pharmaceutically acceptable salts thereof useful for the treatment of cerebralvascular, cardio-circula- tory and epipletic afflictions; their preparation of the same by a synthesis sequence starting from a trypt- amine and a 3-halopyruvate and involving a rearrangment of an addition compound with an aldehyde; said rearrange- ment being effected by Nb-alkylation of the aforementioned addition compound; and to pharmaceutical compositions containing the same.

401623

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