Pyrrolo [2, 3 -d] pyrimidin derivatives as protein kinase b...

Details Pyrrolo [2, 3 -d] pyrimidin derivatives as protein kinase b... Pyrrolo [2, 3 -d] pyrimidin derivatives as protein kinase b...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2701057

The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).

La présente invention concerne un nouveau groupe de composés de formule (I) ou des sels de ceux-ci : Y, Z1, Z2, R1, R4, R5 et n étant tels que décrits dans la spécification, qui peuvent être utiles dans le traitement ou la prévention d'une maladie ou condition médicale induite par la protéine kinase B (PKB) telle que le cancer. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés, des procédés de traitement de maladies induites par la PKB utilisant lesdits composés et des procédés de préparation des composés de formule (I).

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