Pyrrolo[2,3-d]pyrimidine compounds

Details Pyrrolo[2,3-d]pyrimidine compounds Pyrrolo[2,3-d]pyrimidine compounds

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) C07D 209/00 (2006.01) C07D 239/00 (2006.01)

Patent

CA 2335186

A compound of formula (I) wherein R1, R2 and R3 are as defined in the formula which are inhibitors of the enzyme protein tyrosine kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppresive agents for organ transplants, lupus, multiple sclesoris, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.

La présente invention concerne des composés de formule, dans laquelle R<1>, R<2> et R<3> sont tels que définis dans la description. Ces composés sont des inhibiteurs d'enzymes tyrosine kinases, telle que la Janus Kinase 3, et en tant que tels, sont des traitements utiles, comme agents immunosuppresseurs dans les transplantations d'organes, du lupus, de la sclérose multiple, de l'arthrite rhumatoïde, du psoriasis, des diabètes de type I et des complications diabétiques, du cancer, d'asthme, de dermatite atopique, de troubles thyroïdiens auto-immuns, de colites ulcérantes, des maladies de Crohn et d'Alzheimer, de leucémies et d'autres maladies auto-immunes.

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