Pyrrolo[2,3-d]pyrimidine compounds

Details Pyrrolo[2,3-d]pyrimidine compounds Pyrrolo[2,3-d]pyrimidine compounds

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) C07D 209/00 (2006.01) C07D 239/00 (2006.01)

Patent

CA 2335492

Image A compound of formula (I) wherein R1, R2 and R3 are as defined in the description, and are inhibitors of the enzyme protein tyrosine kinases such as Janus Kinase (3) and as such are useful therapy as immunosuppressive agents for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.

La présente invention concerne des composés de formule, dans laquelle R<1>, R<2> et R<3> sont tels que définis dans la description. Ces composés sont des inhibiteurs d'enzymes tyrosine kinases, telle que la Janus Kinase 3, et en tant que tels, sont des traitements utiles, comme agents immunosuppresseurs dans les transplantations d'organes, du lupus, de la sclérose multiple, de l'arthrite rhumatoïde, du psoriasis, des diabètes de type I et des complications diabétiques, du cancer, d'asthme, de dermatite atopique, de troubles thyroïdiens auto-immuns, de colites ulcérantes, des maladies de Crohn et d'Alzheimer, de leucémies et d'autres maladies auto-immunes.

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