Pyrrolo[2,3-d]pyrimidine compounds

Details Pyrrolo[2,3-d]pyrimidine compounds Pyrrolo[2,3-d]pyrimidine compounds

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/365 (2006.01) A61K 31/445 (2006.01) A61K 31/519 (2006.01) A61K 38/13 (2006.01) A61P 37/00 (2006.01) C07D 209/00 (2006.01) C07D 239/00 (2006.01)

Patent

CA 2393640

A compound of formula (I) wherein Rl, R2 and R3 are as defined above, which are inhibitors of the enzyme protein kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppressive agents for organ transplants, xeno transplantation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.

La présente invention concerne un composé de formule (I), dans laquelle R<1>, R<2> et R<3> sont tels que définis ci-dessus. Les composés selon cette invention sont des inhibiteurs des protéines kinases enzymatiques, telles que Janus Kinase 3, et en tant que tels, sont utilisés à des fins thérapeutiques, en tant qu'agents immunosuppresseurs, en cas de transplantation d'organes, de xénotransplantation, de lupus, de sclérose en plaques, de polyarthrite rhumatoïde, de psoriasis, de diabète de type I et de complications issues de diabètes, du cancer, de l'asthme, de dermatite atopique, de troubles thyroïdiens auto-immuns, de recto-colite ulcéro-hémorragique, de la maladie de Crohn, de la maladie d'Alzheimer, de la leucémie et d'autres maladies auto-immunes.

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