Pyrrolo [3, 2 -d] pyrimidines as dpp-iv inhibitors for the...

Details Pyrrolo [3, 2 -d] pyrimidines as dpp-iv inhibitors for the... Pyrrolo [3, 2 -d] pyrimidines as dpp-iv inhibitors for the...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 7/12 (2006.01)

Patent

CA 2660197

The present invention relates to substituted pyrrolo[3,2-d]pyrimidines of formula (I), wherein R1 and R2 are defined as in claim 1, including the tautomers, stereoisomers, mixtures and salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

La présente invention concerne des pyrrolo[3,2-d]pyrimidines substituées répondant à la formule (I), R1 et R2 étant définis dans la revendication 1, ainsi que leurs tautomères, stéréoisomères, mélanges et sels. Ces composés sont dotés de propriétés pharmacologiques précieuses, particulièrement sur le plan de l'effet inhibiteur sur l'activité de l'enzyme dipeptidylpeptidase-IV (DPP-IV).

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