C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) C07D 401/14 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2386795
The invention relates to 3-pyrrolo imidazole derivatives of general formula (I), wherein: the imidazole radical is an optionally substituted imidazole cycle; X, Y, A and B, independent of one another, represent carbon atoms or nitrogen atoms; radicals Z, independent of one another, represent a hydrogen atom, a halogen atom, a pseudohalogen, an optionally substituted alkyl radical, alkenyl radical, alkynyl radical, aralkyl radical, aralkenyl radical, aralkynyl radical, cycloalkyl radical, cycloalkenyl radical, cycloalkynyl radical, cycloaralkyl radical, cycloaralkenyl radical, cycloaralkynyl radical, aryl radical, alkoxy radical or an optionally substituted ring, on which one or two additional optionally substituted rings can be anellated, and/or at least two of the radicals Z can be part of an optionally substituted ring, on which one or two additional optionally substituted rings can be anellated. The invention also relates to pharmaceutical compositions which contain at least one of the aforementioned compounds, optionally in conjunction with conventional supports and/or adjuvants and/or auxiliary agents, and to their use, in particular, as medicaments which resolve tumors and cancer, and which, quite particularly, are used as antibiotic, in particular, antibacterial medicaments.
L'invention concerne des dérivés de 3-pyrrolo-imidazol de la formule générale (I) dans laquelle le reste imidazol est un cycle imidazol éventuellement substitué, X,Y,A et B désignent indépendamment les uns des autres des atomes de carbone ou d'azote, les restes Z désignent indépendamment les uns des autres un atome d'hydrogène, un atome d'halogène, un pseudohalogène, un reste alkyle, alkényle, alkinyle, aralkyle, aralkényle, aralkinyle, cycloalkyle, cycloalkényle, cycloalkinyle, cycloaralkyle, cycloaralkényle, cycloaralkinyle, aryle, alcoxy, ledit reste étant dans chaque cas éventuellement substitué ou un composé cyclique éventuellement substitué, sur lequel peuvent être annelés un ou deux autres composés cycliques éventuellement substitués. L'invention concerne en outre des préparations pharmaceutiques contenant au moins un des composés précités, éventuellement en combinaison avec des excipients et/ou des adjuvants et/ou des auxiliaires classiques.
Beck Barbara
Doemling Alexander
Macrae & Co.
Morphochem Ag
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