Pyrrolo pyrimidines as agents for the inhibition of cystein...

Details Pyrrolo pyrimidines as agents for the inhibition of cystein... Pyrrolo pyrimidines as agents for the inhibition of cystein...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2458684

The invention provides compounds of Formula I or a pharmaceutically acceptable salt or ester thereof wherein the symbols have meaning as defined, which are inhibitors of cathepsin K and find use pharmaceutically for treatment of diseases and medical conditions in which cathepsin K is implicated, e.g. various disorders including inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis and tumors.

L'invention concerne des composés représentés par la formule (I) ou un de leurs sels ou esters acceptable sur le plan pharmaceutique, dans laquelle les symboles possèdent les significations définies, ces composés étant des inhibiteurs de cathepsine K et pouvant être utilisés dans le domaine pharmaceutique afin de traiter des maladies et des états impliquant cathepsine K, par exemple, différentes maladies, telles que l'inflammation, la polyarthrite rhumatoïde, l'ostéoarthrite, l'ostéoporose ou les tumeurs.

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