Pyrroloazepine derivatives

Details Pyrroloazepine derivatives Pyrroloazepine derivatives

C - Chemistry, Metallurgy

07

D

167/209, 260/241

C07D 487/04 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2035749

Disclosed herein are pyrroloazepine derivatives represented by the following formula (I): (see formula I) wherein R means a hydrogen atom, a linear or branched C1-6 alkyl group or a C7-10 aralkyl group, A denotes a linear or branched C2-10 alkylene, alkenylene or alkynylene group, Z stands for O, NOR1 or NOCOR5 in which R1 and R5 is a hydrogen atom or an alkyl, aryl or aralkyl group, and Y means a particular piperidinyl or pyrrolidinyl group; and salts thereof. Their prepara- tion processes are also disclosed. These derivatives and salts having strong anti-~1 action and anti-serotonin action but low toxicity and being useful as.therapeutics for circulatory diseases such as hypertension and congestive heart failure.

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