Pyrrolobenzimidazolones and their use as antiproliferative...

Details Pyrrolobenzimidazolones and their use as antiproliferative... Pyrrolobenzimidazolones and their use as antiproliferative...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4184 (2006.01) C07D 209/00 (2006.01) C07D 235/00 (2006.01)

Patent

CA 2569088

The invention relates to pyrrolobenzimidazolone compounds of formula (I), wherein A, T and R1 to R3 are defined as in claim 1, which possess tubulin inhibitory activity and are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation and the use thereof for preparing a pharmaceutical composition.

L'invention concerne des composés de pyrrolobenzimidazolone de formule (I), dans laquelle A, T et R¿1? à R¿3? sont tels que définis dans la revendication 1. Ces composés présentent une activité inhibitrice de la tubuline et sont appropriés au traitement de maladies caractérisées par une prolifération cellulaire excessive ou anormale. Cette invention a aussi trait à leur utilisation dans la préparation d'une composition pharmaceutique.

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