Pyrrolobenzodiazepines

Details Pyrrolobenzodiazepines Pyrrolobenzodiazepines

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/551 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2505489

Compounds of formula (I) : formula (I) and salts, solvates, chemically protected forms, and prodrugs thereof, are disclosed wherein R2 is selected from: an optionally substituted napthyl group; an optionally substituted thiophenyl or furanyl group; and a phenyl group substituted by: one or more chloro or fluoro groups; an ethyl or propyl group; a 4-t-butyl group; a 2- methyl group; or two methyl groups in the 2- and 6- positions.

L'invention concerne de composés de la formule (I) ainsi que des sels, des solvates, des formes chimiquement protégées et des promédicaments de ceux-ci, formule dans laquelle R?2¿ est choisi entre : un groupe napthyle facultativement substitué ; un groupe thiophényle ou furanyle facultativement substitué ; et un groupe phényle substitué par : un ou plusieurs groupes chloro ou fluoro ; un groupe éthyle ou propyle ; un groupe 4-t-butyle ; un groupe 2-méthyle ; ou deux groupes méthyle dans les positions 2 et 6.

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