C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2127689
2127689 9315079 PCTABS00024 Pyrroloimidazolyl and imidazopyridinyl substituted 1H^_-benzimidazole derivatives having formula (I) wherein n is 0 or 1; R1 is hydrogen, nitro, amino, mono- or diC1-6alkyl)amino, halo, C1-6alkyl, hydroxy or C1-6alkyloxy; R2 is hydrogen; C1-10alkyl; C3-6alkenyl; C3-6alkynyl; C3-7cycloalkyl; phenyl; substituted phenyl; C1-4alkyl substituted with phenyl, substituted phenyl, naphthalenyl, thienyl, furanyl, C1-4alkylfuranyl, C3-7cycloalkyl; and R3 is hydrogen, C1-8alkyl; C3-7cycloalkyl; hydroxy, amino; C1-6alkyloxy; C1-6alkyloxycarbonylamino; phenyl; C1-4alkyl substituted with phenyl, piperazinyl, 4-(C1-4alkyl)piperazinyl or morpholinyl; each substituted phenyl independently is phenyl substituted with a substituent independently selected from halo, hydroxy, hydroxymethyl, trifluoromethyl, C1-6alkyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, formyl, (hydroxyimino)methyl, cyano, amino, mono- and di(C1-6alkyl)amino and nitro, having sex hormone synthesis inhibiting properties. Compositions containing said compounds of formula (I). Preparations of said compounds and compositions, and use thereof for treating mammals suffering from sex hormone disorders.
Freyne Eddy J. E.
Greco Michael N.
Janssen Marcel A. C.
Raeymaekers Alfons H. M.
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica N.v.
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