C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2278682
Novel carbamoyloxypyrroloindole derivatives represented by general formula (1) and having antimicrobial and antitumor activities, optical isomers thereof and pharmacologically acceptable salts of the same, and intermediates in producing the same, wherein R1 represents OH or pyrrolidinyl; n is 1 or 2; R2 represents lower (C1-4) alkyl; Y-Y or Y-X represents CH2, CHOH, CH2-CH2 , O-CH2 or NMe-CH2; Z1 represents Cl or Br; and Ar1 represents (a), (b), (c), (d) or (e) (wherein Z2 and Z3 represent each O or NH; m is an integer of 1 to 4; and Ar2 represents either of the above a, b, c and d).
L'invention porte sur de nouveaux dérivés de carbamoyloxypyrrolindole de la formule générale (1) qui ont une activité antimicrobienne et antitumorale, sur des isomères optiques et sels pharmaceutiquement acceptables desdits dérivés, et sur des substances intermédiaires permettant de produire lesdits dérivés. Dans ladite formule générale (1), R<1> est OH ou pyrrolidinyle; n est 1 ou 2; R<2> est alkyle inférieur en C1-4; Y-Y ou Y-X est CH2, CHOH, CH2-CH2, O-CH2 ou NMe-CH2; Z<1> est Cl ou Br; et Ar<1> est représenté par les formules (a), (b), (c), (d) ou (e) dans lesquelles Z<2> et Z<3> sont chacun O ou NH; m est un entier compris entre 1 et 4; et Ar2 est l'une quelconque des formules (a), (b),
Fukuda Yasumichi
Oomori Yasuo
Shimazawa Rumiko
Terashima Shiro
Kyorin Pharmaceutical Co. Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Sagami Chemical Research Center
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