C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4985 (2006.01)
Patent
CA 2587894
The present invention relates to compounds of formula (I): wherein x, R1, R2 and R3 denote as in Claim 1, useful as inhibitors of Aurora protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of usig the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
La présente invention concerne des composés représentés par la formule (I) et convenant comme inhibiteurs de la protéine-kinase Aurora. Dans cette formule, R1, R2 et R3 sont tels que spécifiés dans la 1ère revendication. L'invention concerne également, d'une part des compositions pharmaceutiquement admises et comprenant ces composés, et d'autre part des procédés pour utiliser ces compositions pour le traitement de divers états, troubles ou affections. L'invention concerne enfin des procédés permettant d'élaborer les composés de l'invention.
Binch Hayley
Fraysse Damien
Miller Andrew
Robinson Daniel
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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