Pyrrolopyridazine compound

Details Pyrrolopyridazine compound Pyrrolopyridazine compound

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/5025 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2399380

A pyrrolopyridazine compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. (In the formula, R1 is C2-6 alkenyl, C2-6 halogenoalkenyl, optionally substituted C3-7 cycloalkyl, or optionally substituted C1-6 alkyl substituted by C3-7 cycloalkyl; R2 is C1-6 alkyl; R3 is hydroxymethyl, C2-6 aliphatic acyloxymethyl, optionally substituted (C6-10 aryl)carbonyloxymethyl, (C1-6 alkoxy)carbonyloxymethyl, formyl, carboxy, (C1-6 alkoxy)carbonyl, or optionally substituted (C6-10 aryl)oxycarbonyl; R4 is optionally substituted C6-10 aryl; and A is imino, oxygen, or sulfur.) The pyrrolopyridazine compound is highly effective in inhibiting the secretion of gastric hydrochloric acid, protecting the gastric mucosa, and the like. It is useful as a medicine, especially a preventive/remedy for ulcerative diseases.

L'invention porte sur un composé de pyrrolopyridazine représenté par la formule générale (I) ou un sel de celui-ci acceptable d'un point de vue pharmacologique. (Dans la formule (I), R?1¿ représente alcényle C¿2-6?, halogénoalcényle C¿2-6?, cycloalkyle C¿3-7? éventuellement substitué ou alkyle C¿1-6? éventuellement substitué par cycloalkyle C¿3-7?; R?2¿ représente alkyle C¿1-6?; R?3¿ représente hydroxyméthyle, acyloxyméthyle aliphatique C¿2-6?, (C¿6-10? aryl)carbonyloxyméthyle éventuellement substitué, (C¿1-6? alcoxy)carbonyloxyméthyle, formyle, carboxy, (C¿1-6? alcoxy)carbonyle ou (C¿6-10? aryl)oxycarbonyle éventuellement substitué ; R?4¿ représente aryle C¿6-10? éventuellement substitué ; et A est amino, oxygène ou soufre). Le composé de pyrrolopyridazine est extrêmement efficace pour inhiber la sécrétion de l'acide chlorhydrique gastrique, protéger les muqueuses gastriques et analogue. Il peut être utilisé en médecine, notamment comme prévention/remède des maladies ulcératives.

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