Pyrrolopyridine derivatives as protein kinase inhibitors

Details Pyrrolopyridine derivatives as protein kinase inhibitors Pyrrolopyridine derivatives as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2608333

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the CDKs, Aurora, Jak2, Rock, CAMKII, FLT3, Tie2, TrkB, FGFR3 and KDR kinases.

L'invention concerne une nouvelle classe de composés, compositions pharmaceutiques comprenant de tels composés ainsi que des procédés d'utilisation pour traiter ou prévenir des maladies ou des troubles associés à l'activité anormale ou déréglée de la kinase, plus spécifiquement des maladies ou troubles mettant en oeuvre l'activation anormale de CDKs, Aurora, Jak2, Rock, CAMKII, FLT3, Tie2, TrkB, FGFR3 et KDR kinases.

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