Pyrrolopyrimidine and pyrrolotriazine derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01)

Patent

CA 2552503

An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastral diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, dermatitides, schizophrenia, pain, etc. A pyrrolopyrimidine or pyrrolotriazine derivative substituted with a carbamoyl group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

L'objectif de l'invention est de créer un antagoniste des récepteurs de la corticolibérine (CRF) qui est efficace comme agent thérapeutique ou prophylactique pour des maladies dans lesquelles la CRF tend à croître, telles que la dépression, l'anxiété, la maladie d'Alzheimer, la maladie de Parkinson, la chorée d'Huntington, les troubles alimentaires, l'hypertension, les maladies gastriques, la dépendance médicamenteuse, l'épilepsie, l'infarctus cérébral, l'ischémie cérébrale, l'oedème cérébral, une blessure externe céphalique, l'inflammation, les maladies associées à l'immunité, l'alopécie, le colon irritable, les troubles du sommeil, les dermatites, la schizophrénie, la douleur, etc. L'invention concerne également un dérivé de pyrrolopyrimidine ou de pyrrolotriazine substitué par un groupe carbamoyle de formule (I), ce dernier présentant une grande affinité avec les récepteurs de la CRF et étant efficace contre les maladies, dans lesquelles la CRF tend à croître.

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