C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/505 (2006.01)
Patent
CA 2556946
According to the present invention, there is provided an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastro-intesinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, pain, etc. A pyrrolopyrimidine derivative represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.
La présente invention fournit un antagoniste contre des récepteurs CRF efficace en tant qu~agent thérapeutique ou prophylactique pour les maladies pour lesquelles on considère que le CRF est impliqué, comme la dépression, l~anxiété, la maladie d~Alzheimer, la maladie de Parkinson, la maladie de Huntington, les troubles alimentaires, l~hypertension, les maladies gastro-intestinales, la dépendance aux médicaments, l~infarctus cérébral, l~ischémie cérébrale, l~.oelig.dème cérébral, les blessures céphaliques externes, l~inflammation, les maladies relatives à l~immunité, l~alopécie, le syndrome du côlon irritable, les troubles du sommeil, l~épilepsie, l~eczéma, la schizophrénie, la douleur, etc. Dérivé pyrrolopyrimidine représenté par la formule suivante [I] : possède une grande affinité avec les récepteurs CRF et est efficace contre les maladies dans lesquelles le CRF est impliqué.
Bischoff Francois P.
Braeken Mirielle
Diels Gaston S. M.
Kennis Ludo E. J.
Nakazato Atsuro
Bischoff Francois P.
Braeken Mirielle
Diels Gaston S. M.
Kennis Ludo E. J.
Nakazato Atsuro
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