Pyrrolopyrimidine derivatives

Details Pyrrolopyrimidine derivatives Pyrrolopyrimidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 3/10 (2006.01) A61P 17/14 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2477116

(I) Pyrrolo[3,2-d] pyrimidine derivatives represented by the above general formula (I) or pharmaceutically acceptable salts thereof. Because of having a GSK-3 inhibitory effect, these compounds are expected as being useful as remedies or preventives for diseases in which GSK-3 participates such as diabetes, diabetic complications, Alzheimer~s disease, neurodegenerative disease, depression and mania, traumatic brain injury, hair loss, inflammatory diseases, cancer and immunodeficiency.

La présente invention concerne des dérivés de pyrrolo[3,2-d]pyrimidine représentés par la formule (I) ou des sels pharmaceutiquement acceptables de ces derniers. Du fait de leur effet inhibiteur GSK-3, ces composés sont supposés être utiles en tant que remèdes ou préventifs pour des maladies dans lesquelles le GSK-3 joue un rôle, telles que le diabète, les complications du diabète, la maladie d'Alzheimer, les maladies neurodégénératives, la dépression et les manies, la lésion cérébrale acquise, la chute des cheveux, les maladies inflammatoires, le cancer et l'immunodéficience. Formule (I)

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