Pyrrolopyrimidine derivatives, their production and use

Details Pyrrolopyrimidine derivatives, their production and use Pyrrolopyrimidine derivatives, their production and use

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 487/04 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2031769

Abstract of the disclosure: Compounds of the formula: Image wherein the ring ? is a pyrrole ring which may be hydrogenated; X is an amino, hydroxyl or mercapto group; Y is a hydrogen or hydroxyl group; -COOR1 and -COOR2 independently represents a carboxyl group which may be esterified; - ? - is a cycloalkylene ox cyclolkenylene group which may be substituted or a phenylene group which is substituted; Z is a divalent C2 4 aliphatic group of straight chain which may be substituted or its salt. Their production is characterized by reacting the compound of the formula, Image ? - COOR3 wherein -COOR3 is a carboxyl group which may be esterfied; ? , X, Y, Z and - ? - are the same as defined above, or their reactive derivatives in the carboxyl group with the compounds of the formula. Image 1 2 [wherein -COOR and -COOR are the same as defined above]. The product compound and their caits have inhibitory activity against enzymes which utilize folic acid or its related compound as a substrate, and axe employable for treating tumors.

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