Pyrrolopyrimidines

Details Pyrrolopyrimidines Pyrrolopyrimidines

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) C07D 209/00 (2006.01) C07D 239/00 (2006.01)

Patent

CA 2471538

Pyrrolopyrimidine derivatives of the formula I (see formula I) in which R3, R4, R5, R6 and X are as defined in Claim 1, act as phosphodiesterase VII inhibitors and can be employed for the treatment of osteoporosis, tumours, cachexia, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, inflammatory processes, allergies, asthma, autoimmune diseases, myocardial diseases and AIDS.

La présente invention concerne des dérivés de pyrrolo-pyrimidine de formule (I) dans laquelle R?3¿, R?4¿, R?5¿, R?6¿ et X ont les correspondances indiquées dans la revendication 1. Ces dérivés agissent en tant qu'inhibiteurs de phosphodiestérase VII et peuvent être utilisés pour traiter l'ostéoporose, les tumeurs, la cachexie, l'athérosclérose, l'arthrite rhumatoïde, la sclérose en plaques, le diabète sucré, les phénomènes d'inflammation, les allergies, l'asthme, les maladies auto-immunes, les maladies du myocarde et le SIDA.

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